Rapamycin (Sirolimus) is an mTOR inhibitor traditionally used as an immunosuppressant in transplant medicine. In recent years, it has gained growing interest in the field of longevity and anti-aging medicine due to its ability to modulate cellular aging, inflammation, and metabolic health. When dosed intermittently and at low levels, Rapamycin may help extend lifespan, delay age-related disease onset, and support health span without the immune suppression associated with high-dose use.

Rapamycin works by selectively inhibiting the mammalian target of rapamycin complex 1 (mTORC1), a key regulator of aging and growth:

mTORC1 Inhibition
• mTORC1 controls cell growth, proliferation, and protein synthesis. Rapamycin slows this pathway, promoting cellular repair, autophagy, and metabolic efficiency—hallmarks of anti-aging.

Reduces Inflammaging
• Rapamycin lowers chronic low-grade inflammation and may reduce risk of diseases like cancer, Alzheimer’s, cardiovascular disease, and metabolic syndrome.

Intermittent, Low-Dose Strategy
• When used once or twice weekly at low doses, it avoids immunosuppression while preserving its anti-aging and regenerative benefits.